"Toff Plus" is a combined remedy for the elimination of cold symptoms and ARI.
The drug consists of several components.Paracetamol in its composition has analgesic and antipyretic effects. Alpha-adrenomimetic phenylephrine produces a vasoconstrictor effect, helps to relieve the patient from stuffiness in the nose, reduce the amount of mucosal secretion from his cavity.
Chlorphenamine promotes blocking of H1-gistaminovyh receptors, hasantiallergic effect, suppresses signs of allergic rhinitis (reduces vascular permeability, removes flushing and swelling of the nasal mucosa).
Dextromethorphan is a remedy for coughing, closeon the strength of the action to codeine, which increases the sensitive threshold of the cough center in the medulla oblongata, which depresses all types of cough and eliminates irritation caused by an unproductive dry cough. It is well tolerated by any age group. The drug "Toff Plus" has a certain sedative effect, does not have sleeping pills, narcotic and analgesic effects.
The activity of the ciliated epithelium and the respiratory center does not depress. The drug starts to act after 20-30 minutes, the duration of its functioning - about four hours.
According to instructions to "Toff Plus", in oneThe capsule contains: paracetamol, dextromethorphan hydrobromide, phenylephrine hydrochloride, chlorophenamine maleate. Auxiliary components are as follows: croscarmellose sodium, povidone, talc, gelatin, sodium disulfite, microcrystalline cellulose, sucrose, cellulose acetate phthalate, yellow quinoline dye, diethyl phthalate, blue diamond dye, crimson dye. The shell contains gelatin, water, sodium lauryl sulfate, blue diamond dye, propyl parahydroxybenzoate and methyl parahydroxybenzoate.
Below is the price of Toff Plus. The instruction does not contain such information.
Form of issue
Producers have developed two forms of product release, which is very convenient for people, since it is possible to buy the necessary drug with minimal financial resources.
In the blisters of aluminum foil and PVC contains ten capsules. In the carton - one or two blisters with a nested instruction.
When is it applied?
Toff Plus is appointed in the following cases:
- inflammatory-infectious (catarrhal) diseases, including influenza, rhinopharyngitis, ARVI, rhinitis;
- rhinitis of an allergic nature.
As the instruction to "Toff Plus" indicates, the contraindications to the application are as follows:
- excessive sensitivity;
- lack of glucose-6-phosphate dehydrogenase;
- simultaneous use of MAO inhibitors, tricyclic antidepressants, as well as beta-blockers;
- blood pathology;
- glaucoma is closed-angle;
- kidney and / or liver failure;
- hyperplasia of the prostate;
- hypertension of arterial type;
- Gilbert's syndrome;
- lactation period;
- bronchial asthma;
- the patient's age is up to fourteen years.
Caution should be in the presence of GOKMP, angina and in old age.
"Toff Plus" is taken orally, one capsuleevery 4-6 hours, but not more than four capsules per day. As a means of reducing fever, is used no longer than three days in the absence of medical advice.
When using the drug, there may be the following side effects:
- nervous system, as well as sensory organs: drowsiness, mydriasis, dizziness, excessive excitability, increased pressure inside the eye, paresis of accommodation;
- system of digestion: dryness in the oral cavity, vomiting, epigastric pain, hepatotoxic effect, nausea;
- hemopoietic organs: aplastic anemia, thrombocytopenia, anemia, hemolytic anemia;
- urinary system: papillary necrosis (nephrotoxicity), urine retention;
- reactions of an allergic nature: rash on the skin, bronchial obstruction, angioedema, itching;
- other symptoms: increased blood pressure.
Reviews about "Toff Plus" confirm this.
The drug requires verycareful treatment, so that the use of an excess dose does not harm the patient's health. In particular, this applies to adolescents, children, the elderly and people who are in a state of drug or alcohol intoxication.
That's why, for all the strange symptoms onDrug use should be referred to a doctor. As a rule, signs of overdose occur when taking more than 10-15 grams of the drug.
The main symptoms of drug use in excessive amounts are as follows:
- pallor of mucous membranes and skin, vomiting, nausea, allergic reactions, reduction of blood coagulability;
- allergic manifestations;
- a network of vessels around the eye cornea;
- frequent heartbeat, arrhythmia, arterial hypertension;
- acute retention of urine;
- vomiting, jaundice, liver or kidney failure;
- hematopoietic disorders;
- suppression of the nervous system, confusion, drowsiness.
When these symptoms manifest themselves, treatmentthe following: gastric lavage, reception of "Polysorb", activated carbon, N-acetylcysteine, methionine. With a strong expression of signs of an overdose, immediate intervention by a specialist is necessary.
In accordance with the instructions for use, "Toff Plus" increases the effectiveness of ethanol, sedatives, MAO inhibitors.
Antiparkinsonian drugs, antidepressants, antipsychotic medications, phenothiazine derivatives increase the likelihood of urine retention, constipation and dryness in the oral cavity.
SCS increases the risk of glaucoma.
Because of paracetamol, the effect of uricosuric medicines is reduced.
Chlorphenamine, which is prescribed at one time with furazolidone and MAO inhibitors, can lead to hypertensive crisis, high temperature and the excitation of psychomotorics.
Tricyclic antidepressants contribute to the increase of sympathomimetic influence, simultaneous administration of halothane increases the risk of arrhythmia of the ventricles.
The drug reduces the hypotensive effect of guanethidine, which enhances phenylephrine alpha-adrenostimulating activity.
Do not use other drugs containing substances that are part of the drug.
In patients who have chronic alcohol dependence, taking medication at therapeutic dosage can cause serious kidney failure.
During the treatment should refrain from taking ethanol, because hepatotoxic effects may develop. This is confirmed by the instruction on the application to "Toff Plus".
Also, during therapy, one should refrain from driving motor vehicles and other potentially dangerous occupations that require high concentration and speed of psychomotor reactions.
Terms of purchase in the pharmacy, the price
Leave from the drugstores "Toff Plus" by order is carried out without presenting a doctor's prescription. The price is about one hundred rubles, fluctuating in regions insignificantly.
Storage conditions and terms
The medicine should be stored in a dry place, protected from light and children's access. Storage temperature should not exceed 25 degrees Celsius.
"Toff Plus" has the following analogues, which are the most similar in their pharmacological influence: Tamiflu, Efferalgan, Rint, Rinza, Novirin, Flikold Knight, Maxikold.
Also popular are Coldrex Knight, Migrenol Extra, Paralen Extra, Pentalgin, Rinzasip, Rincold, Influblok.
People confirm that the drug is very effectiveand inexpensive. He quickly removes lethargy and weakness, relieves of a cold and sore throat. The medicine is really time-tested and used in families for the treatment of all household members.
According to reviews, "Toff Plus" facilitates the signs of ARI andcold, in its composition there is paracetamol. The composition is quite harmless, the drug removes symptoms gradually and gently. Affordable price also attracts patients.
The most important thing is to use the medicine correctly. In a few reviews, lack of due effectiveness is indicated as a defect.